The phenotypic data. PPG participated in PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25447644 the design of the study. AB conceptualized

The phenotypic data. PPG participated in PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25447644 the design of the study. AB conceptualized the study and collected the phenotypic data. GG and JPL conceptualized and supervised the whole study, analyzed the data, performed the statistical analysis, drafted the manuscript. All authors read and approved the final version of the manuscript. Author details 1 Instituto de Gen ica Veterinaria (IGEVET), CCT La Plata ?CONICET – Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Calle 60 y 118 s/n, La Plata B1900AVW, CC 296, Argentina. 2Departamento de Producci Animal, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina. 3Fellow of the Consejo Nacional de Investigaciones Cient icas y T nicas (CONICET), La Plata, Argentina. Received: 18 July 2014 Accepted: 12 September 2014 Published: 16 September 2014 References 1. Ojeda SR, Dubay C, Lomniczi A, Kaidar G, Matagne V, Sandau US, Dissen GA: Gene networks and the neuroendocrine regulation of puberty. Mol Cell Endocrinol 2010, 324:3?1. 2. Johnston DJ, Barwick SA, Corbet NJ, Fordyce G, Holroyd RG, Williams PJ, Burrow HM: Genetics of heifer puberty in two tropical beef genotypes in northern Australia and associations with heifer and steer-production traits. Anim Prod Sci 2009, 49:399?12. 3. Fortes MRS, Lehnert SA, Bolormaa S, Reich C, Fordyce G, Corbet NJ, Whan V, Hawken RJ, Reverter A: Finding genes for economically important traits: Brahman cattle puberty. Anim Prod Sci 2012, 52:143?50. 4. Warner A, Mittag J: AZD0156 site thyroid hormone and the central control of homeostasis. J Mol Endocrinol 2012, 49:29?5. 5. Mullur R, Liu YY, Brent GA: Thyroid hormone regulation of metabolism. Physiol Rev 2014, 94(Suppl2):355?82. 6. Jannini EA, Crescenzi A, Rucci N, Screponi E, Carosa E, de Matteis A, Macchia E, d’Amati G, D’Armiento M: Ontogenetic pattern of thyroid hormone receptor expression in the human testis. J Clin Endocrinol Metab 2000, 85:3453?457. 7. Mendis-Handagama SM, Siril Ariyaratne HB: Leydig cells, thyroid hormones and steroidogenesis. Indian J Exp Biol 2005, 43(Suppl11):939?62. 8. Flood DE, Fernandino JI, Langlois VS: Thyroid hormones in male reproductive development: evidence for direct crosstalk between the androgen and thyroid hormone axes. Gen Comp Endocrinol 2013, 192:2?4.Fern dez et al. Journal of Animal Science and Technology 2014, 56:17 http://www.janimscitechnol.com/content/56/1/Page 4 of9.10. 11.12.13.14.15.16. 17.18.19. 20. 21. 22.23.24.25.Duarte-Guterman P, Navarro-Mart L, Trudeau VL: Mechanisms of crosstalk between endocrine systems: Regulation of sex steroid hormone synthesis and action by thyroid hormones. Gen Comp Endocrinol 2014, doi:10.1016/j. ygcen.2014.03.015. Wagner MS, Wajner SM, Maia AL: Is there a role for thyroid hormone on spermatogenesis? Microsc Res Tech 2009, 72:796?08. Krassas GE, Papadopoulou F, Tziomalos K, Zeginiadou T, Pontikides N: Hypothyroidism has an adverse effect on human spermatogenesis: A prospective, controlled study. Thyroid 2008, 18(Suppl12):1255?259. Ram PA, Waxman DJ: Pretranslational control by thyroid hormone of rat liver steroid 5 alpha-reductase and comparison to the thyroid dependence of two growth hormone-regulated CYP2C mRNAs. J Biol Chem 1990, 265(31):19223?9229. Zhou RJ, Bonneaud N, Yua CX, Barbara PD, Boizet B, Tibor S, Scherer G, PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28192408 Roeder RG, Poulat F, Berta P: SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex. Nucleic Acids Res 2002, 30(Suppl 14):3245?252.