.4 IC50233.9 36.eight 27.7 36.eight 27.7 three.four 233.9 36.eight 27.7 36.eight 27.7 3.four 233.9 36.8

.4 IC50233.9 36.eight 27.7 36.eight 27.7 three.four 233.9 36.eight 27.7 36.eight 27.7 3.four 233.9 36.8 27.7 3.four 233.9 three.four 233.9 three.43.four 233.9 233.9 three.4 233.9 three.four 233.9 36.8 27.7 3.4 233.9 36.8 27.7 3.four 233.9 3.four 233.9 36.8 27.7 three.four 233.9 36.eight 27.7 42.eight 42.eight 36.eight 27.7 36.eight 27.7 36.8 27.7 42.eight 42.8 36.8 27.7 36.8 27.7 36.8 27.7 36.eight 27.7 42.eight 36.8 27.7 36.8 27.7 42.8 42.eight 36.eight 27.7 42.8 42.8 42.8 39.8 39.eight 42.eight 42.8 42.8 39.eight 39.eight 42.eight 42.8 42.eight 39.eight 42.eight 42.8 39.eight 39.eight 42.eight 39.eight 39.8 9.0 12.9 9.0 12.9 39.eight 9.0 12.9 9.0 12.9 39.8 39.eight 39.8 39.8 39.8 9.0 12.9 39.eight 39.8 39.8 9.0 12.9 9.0 12.9 39.eight 9.0 12.9 39.8 4.4 6.five four.4 6.five 9.0 12.9 4.four six.five four.4 6.5 9.0 12.9 9.0 12.9 four.4 6.five 9.0 12.9 9.0 12.9 9.0 12.9 9.04.4 12.9 9.0 12.9 9.0 12.9 four.four six.five six.5 9.0 12.9 four.four six.five 9.0 12.9 9.0 12.9 four.4 six.5 47.8 76.0 47.eight 76.0 four.four 6.5 47.8 76.0 47.8 76.0 4.4 six.5 four.four six.5 47.8 76.0 4.4 six.five four.4 6.5 six.5 47.8 76.0 4.44.four 6.5 47.8 76.0 four.4 six.five 4.four 6.5 47.8 76.0 four.4 6.5 47.eight 76.0 13.four 17.eight 47.8 76.0 13.four 17.eight 13.four 17.eight 47.8 76.0 13.4 17.eight 47.eight 76.0 47.eight 76.0 47.8 76.0 47.8 76.0 13.four 17.eight 47.8 76.0 47.eight 76.0 47.eight 76.0 13.4 17.eight 13.4 17.eight 47.eight 76.0 13.four 17.eight 47.8 76.0 13.4 17.8 28.1 27.five 13.4 17.8 28.1 27.five 28.1 27.five 13.four 17.8 28.1 27.five 13.4 17.8 13.four 17.8 13.four 17.eight 13.4 17.eight 13.four 17.eight 28.1 27.5 13.four 17.8 13.4 17.eight 28.1 27.five 28.1 27.5 13.four 17.8 28.1 27.five 13.4 17.8 28.1 27.five 28.1 27.5 355.7 300.three 355.7 300.three 28.1 27.five 355.7 300.three 355.7 300.three 28.1 27.five 28.1 27.five 28.1 27.five 28.1 27.five 28.1 27.5 355.7 300.3 28.1 27.five 28.1 27.five 355.7 300.three 355.7 300.3 28.1 27.five 355.7 300.3 355.7 300.3 355.7 300.3 230.three 256.7 230.three 256.7 355.7 300.3 230.3 256.7 355.7 300.3 230.three 256.7 355.7 300.three 355.7 300.three 355.7 300.three 355.7 300.three 230.3 256.7 355.7 300.three 355.7 300.three 230.3 256.7 230.three 256.7 355.7 300.three 230.three 256.7 230.three 256.7 230.three 256.7 230.three 256.7 314.2 421.five 314.2 421.5 230.three 256.7 314.two 421.five 230.three 256.7 314.two 421.five 230.3 256.7 230.three 256.7 230.three 256.7 230.3 256.7 314.2 421.5 230.3 256.7 230.3 256.7 314.two 421.5 314.two 421.5 314.two 421.five 230.three 256.7 314.two 421.five 314.two 421.five 314.2 421.five 47.9 36.7 47.9 36.7 47.9 36.7 314.2 421.5 314.2 421.5 47.9 36.7 314.two 421.five 314.2 421.5 314.2 421.five 47.9 36.7 314.two 421.5 314.2 421.5 47.9 36.7 47.9 36.7 47.9 36.7 314.2 421.five 47.9 36.7 47.9 36.7 47.9 36.7 177.five 287.8 177.5 287.eight 47.9 36.7 177.five 287.eight 47.9 36.7 177.5 287.eight 47.9 36.7 47.9 36.7 47.9 36.7 47.9 36.7 177.five 287.eight 47.9 36.7 47.9 36.7 177.5 287.eight 177.five 287.eight 177.five 287.8 47.9 36.7 177.five 287.8 362.four 318.4 177.5 287.8 362.four 318.4 362.4 318.four 362.4 318.4 177.5 287.8 177.five 287.eight 177.5 287.8 362.four 318.4 177.five 287.eight 362.four 318.four 177.5 287.8 177.5 287.eight 177.5 287.8 362.four 318.4 362.four 318.four 177.five 287.eight 362.four 318.4 362.four 318.four 362.four 318.four 362.four 318.4 362.four 318.4 362.4 318.four 362.four 318.four 362.4 318.4 362.4 318.4 362.4 318.4 362.four 318.Mar. Drugs 2021, 19,23 ofRemoval of the methyl group at R3 led to a reduce in potency against each pathogens (89). This outcome was indeed expected for the Mtb DP MedChemExpress target ClpC1-NTD [96]. This group interacts nicely with the target, that is also closely packed together with the indole motif with the tryptophan core. Nonetheless, it is not yet clear why deletion of this methyl residue impairs activity towards IL-17 web Pfalcp. Modifications of R4 on -methoxyphenylalanine four were also well tolerated (90). The amino- and azido-derivatives 90a and 90b had been equipotent to cyclomarin C, along with the nitro compound 90c was even twice as active. Only in the case of bromo derivative 90d was a substantial drop in activity observed. 7. Conclusions The ilamycins/r