Nterology. 2012; 142:14051. e12. [PubMed: 22001865] 60. Neuschwander-Tetri BA. Hepatic lipotoxicity and the pathogenesis of

Nterology. 2012; 142:14051. e12. [PubMed: 22001865] 60. Neuschwander-Tetri BA. Hepatic lipotoxicity plus the pathogenesis of nonalcoholic steatohepatitis: the central part of nontriglyceride fatty acid metabolites. Hepatology. 2010; 52:7748. [PubMed: 20683968] 61. Pinnick KE, Collins SC, Londos C, Gauguier D, Clark A, Fielding BA. Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. Obesity (Silver Spring). 2008; 16:5220. [PubMed: 18239594] 62. Bourbonnais E, Raymond VA, Ethier C, Nguyen BN, El-Leil MS, Meloche S, Bilodeau M. Liver fibrosis protects mice from acute hepatocellular injury. Gastroenterology. 2012; 142:13039. e4. [PubMed: 21945831]NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptGastroenterology. Author manuscript; accessible in PMC 2014 August 01.Acharya et al.PageNIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptFigure 1. IPF increases with BMI in Controls, AP patients and AP-on-CP individuals but not in CPScatter plot showing the association among IPF and BMI for (A) Controls (black) and CP sufferers (red) and (B) AP sufferers (black) and AP-on-CP individuals (red). Lines represent the best-fit line from a linear regression analysis. Correlation analyses were calculated employing the Spearman’s rho correlation coefficient. Outcomes show moderate to higher correlations in all groups except in CP sufferers. Figure C shows the estimated marginal implies in the twoway ANOVA that incorporated major effects for BMI and group, and their interaction (BMI group). Rank data for IPF (RIPF) was utilized for this evaluation. Post-hoc comparisons were performed using the Sidak adjustment method. Adjusted P values are shown. The two-wayGastroenterology. Author manuscript; readily available in PMC 2014 August 01.Acharya et al.PageANOVA revealed significant key effects for group and BMI, in addition to a considerable interaction. Subsequent post-hoc tests showed that, for the obese group, there had been no statistically significant variations in IPF in between the disease groups; even so, for the normal group, the CP group had significantly higher IPF when when compared with Controls (P value shown in green). Post-hoc comparisons amongst typical (BMI 30) and obese (BMI 30) groups are also shown (P values in black). Figures D and E show linear regression analysis between IPF measured on histology [ IPF (histology)] and Hounsfield units on CT scan or by the CT thresholding approach, respectively.Seralutinib Spearman’s correlation coefficient was computed.RNase Inhibitor NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptGastroenterology.PMID:24187611 Author manuscript; available in PMC 2014 August 01.Acharya et al.PageNIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptFigure 2. Histological quantification of FN (A), PFAN (B), acinar necrosis (C) as percentage of total areaBox plots displaying the mean (dashed line), the median (strong line), the 25th and 75th percentiles (2 boxes), the 10th and 90th percentile (whiskers) as well as the outliers (dots), comparing Controls, CP, AP and AP-on-CP individuals for every from the above parameters show these to be considerably reduced in CP and AP-on-CP in comparison with AP individuals. Important variations were located amongst the groups (Kruskal-Wallis test). Post-hoc comparisons were performed using the Mann-Whitney test and adjustment for several comparisons was performed using the Dunn-Sidak adjustment strategy. Adjusted P values are shown.Gastroenterology. Author manuscript;.