Product Name :
DBCO-NHCO-PEG4-amine
Description:
DBCO-NHCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB−MMAE and DBCO-TRX−MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively).
CAS:
1255942-08-5
Molecular Weight:
523.62
Formula:
C29H37N3O6
Chemical Name:
1-amino-N-(3-{2-azatricyclo[10.4.0.0⁴,⁹]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-3-oxopropyl)-3,6,9,12-tetraoxapentadecan-15-amide
Smiles :
NCCOCCOCCOCCOCCC(=O)NCCC(=O)N1CC2=CC=CC=C2C#CC2=CC=CC=C12
InChiKey:
KTIOBJVNCOFWCL-UHFFFAOYSA-N
InChi :
InChI=1S/C29H37N3O6/c30-13-16-36-18-20-38-22-21-37-19-17-35-15-12-28(33)31-14-11-29(34)32-23-26-7-2-1-5-24(26)9-10-25-6-3-4-8-27(25)32/h1-8H,11-23,30H2,(H,31,33)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
DBCO-NHCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB−MMAE and DBCO-TRX−MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively).|Product information|CAS Number: 1255942-08-5|Molecular Weight: 523.62|Formula: C29H37N3O6|Chemical Name: 1-amino-N-(3-{2-azatricyclo[10.4.0.0⁴,⁹]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-3-oxopropyl)-3,6,9,12-tetraoxapentadecan-15-amide|Smiles: NCCOCCOCCOCCOCCC(=O)NCCC(=O)N1CC2=CC=CC=C2C#CC2=CC=CC=C12|InChiKey: KTIOBJVNCOFWCL-UHFFFAOYSA-N|InChi: InChI=1S/C29H37N3O6/c30-13-16-36-18-20-38-22-21-37-19-17-35-15-12-28(33)31-14-11-29(34)32-23-26-7-2-1-5-24(26)9-10-25-6-3-4-8-27(25)32/h1-8H,11-23,30H2,(H,31,33)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Mifanertinib dimaleate} MedChemExpress|{Mifanertinib dimaleate} c-Met/HGFR|{Mifanertinib dimaleate} Purity & Documentation|{Mifanertinib dimaleate} Formula|{Mifanertinib dimaleate} custom synthesis|{Mifanertinib dimaleate} Autophagy} |Shelf Life: ≥12 months if stored properly.{{1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine} medchemexpress|{1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine} Liposome|{1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine} Biological Activity|{1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine} Data Sheet|{1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine} supplier|{1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24190482 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.|Products are for research use only. Not for human use.|
