Product Name :
COR659
Description:
COR659 is a potent and effective GABAB positive allosteric modulator (PAM). COR659 suppresses alcohol and chocolate self-administration in rats.
CAS:
544450-68-2
Molecular Weight:
337.82
Formula:
C16H16ClNO3S
Chemical Name:
methyl 2-(4-chlorobenzamido)-4-ethyl-5-methylthiophene-3-carboxylate
Smiles :
CC1SC(NC(=O)C2C=CC(Cl)=CC=2)=C(C=1CC)C(=O)OC
InChiKey:
AAFLALGGEYRGTR-UHFFFAOYSA-N
InChi :
InChI=1S/C16H16ClNO3S/c1-4-12-9(2)22-15(13(12)16(20)21-3)18-14(19)10-5-7-11(17)8-6-10/h5-8H,4H2,1-3H3,(H,18,19)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
COR659 is a potent and effective GABAB positive allosteric modulator (PAM).{{Cyclopamine} MedChemExpress|{Cyclopamine} Stem Cell/Wnt|{Cyclopamine} Purity & Documentation|{Cyclopamine} References|{Cyclopamine} manufacturer|{Cyclopamine} Epigenetics} COR659 suppresses alcohol and chocolate self-administration in rats.{{Dotriacontane} site|{Dotriacontane} Technical Information|{Dotriacontane} In stock|{Dotriacontane} manufacturer|{Dotriacontane} Epigenetic Reader Domain} |Product information|CAS Number: 544450-68-2|Molecular Weight: 337.PMID:25016614 82|Formula: C16H16ClNO3S|Chemical Name: methyl 2-(4-chlorobenzamido)-4-ethyl-5-methylthiophene-3-carboxylate|Smiles: CC1SC(NC(=O)C2C=CC(Cl)=CC=2)=C(C=1CC)C(=O)OC|InChiKey: AAFLALGGEYRGTR-UHFFFAOYSA-N|InChi: InChI=1S/C16H16ClNO3S/c1-4-12-9(2)22-15(13(12)16(20)21-3)18-14(19)10-5-7-11(17)8-6-10/h5-8H,4H2,1-3H3,(H,18,19)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (74.00 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|COR659 apparently exerts its effects via a composite mechanism, including positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor.|In Vivo:|COR659 (0, 2.5, 5 and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats. COR659 is able to suppress lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats.|Products are for research use only. Not for human use.|
