Product Name :
TAK-071
Description:
TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM.
CAS:
1820812-16-5
Molecular Weight:
421.46
Formula:
C24H24FN3O3
Chemical Name:
4-fluoro-2-[(3S,4S)-4-hydroxyoxan-3-yl]-5-methyl-6-{[4-(1H-pyrazol-1-yl)phenyl]methyl}-2,3-dihydro-1H-isoindol-1-one
Smiles :
CC1C(F)=C2CN([C@H]3COCC[C@@H]3O)C(=O)C2=CC=1CC1C=CC(=CC=1)N1C=CC=N1
InChiKey:
WFSARWQASFQZMG-VXKWHMMOSA-N
InChi :
InChI=1S/C24H24FN3O3/c1-15-17(11-16-3-5-18(6-4-16)28-9-2-8-26-28)12-19-20(23(15)25)13-27(24(19)30)21-14-31-10-7-22(21)29/h2-6,8-9,12,21-22,29H,7,10-11,13-14H2,1H3/t21-,22-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator.{{Glibenclamide} site|{Glibenclamide} Mitochondrial Metabolism|{Glibenclamide} Biological Activity|{Glibenclamide} In Vitro|{Glibenclamide} supplier|{Glibenclamide} Epigenetics} EC50 of TAK-071 M1R agonist activities is 520 nM.{{Letrozole} medchemexpress|{Letrozole} Cytochrome P450|{Letrozole} Purity & Documentation|{Letrozole} In stock|{Letrozole} custom synthesis|{Letrozole} Autophagy} |Product information|CAS Number: 1820812-16-5|Molecular Weight: 421.PMID:23996047 46|Formula: C24H24FN3O3|Chemical Name: 4-fluoro-2-[(3S,4S)-4-hydroxyoxan-3-yl]-5-methyl-6-{[4-(1H-pyrazol-1-yl)phenyl]methyl}-2,3-dihydro-1H-isoindol-1-one|Smiles: CC1C(F)=C2CN([C@H]3COCC[C@@H]3O)C(=O)C2=CC=1CC1C=CC(=CC=1)N1C=CC=N1|InChiKey: WFSARWQASFQZMG-VXKWHMMOSA-N|InChi: InChI=1S/C24H24FN3O3/c1-15-17(11-16-3-5-18(6-4-16)28-9-2-8-26-28)12-19-20(23(15)25)13-27(24(19)30)21-14-31-10-7-22(21)29/h2-6,8-9,12,21-22,29H,7,10-11,13-14H2,1H3/t21-,22-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 135 mg/mL (320.32 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|TAK-071 increase hippocampal inositol monophosphate production through M1R activation and improved DB00747 -induced cognitive deficits in rats at 0.3 mg/kg.|Products are for research use only. Not for human use.|
