Product Name :
Vesnarinone
Description:
Vesnarinone is a cardiotonic agent, mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. Vesnarinone improves ventricular performance most in patients with the worst degree of heart failure.
CAS:
81840-15-5
Molecular Weight:
395.45
Formula:
C22H25N3O4
Chemical Name:
6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one
Smiles :
COC1=CC=C(C=C1OC)C(=O)N1CCN(CC1)C1=CC2CCC(=O)NC=2C=C1
InChiKey:
ZVNYJIZDIRKMBF-UHFFFAOYSA-N
InChi :
InChI=1S/C22H25N3O4/c1-28-19-7-3-16(14-20(19)29-2)22(27)25-11-9-24(10-12-25)17-5-6-18-15(13-17)4-8-21(26)23-18/h3,5-7,13-14H,4,8-12H2,1-2H3,(H,23,26)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Vesnarinone is a cardiotonic agent, mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. Vesnarinone improves ventricular performance most in patients with the worst degree of heart failure.|Product information|CAS Number: 81840-15-5|Molecular Weight: 395.45|Formula: C22H25N3O4|Synonym:|RG-0210|OPC-8212|Piteranometozine|Vesnarinone|Arkin-Z|RG 0210|RG0210|OPC 8212|OPC8212|Arkin|Chemical Name: 6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one|Smiles: COC1=CC=C(C=C1OC)C(=O)N1CCN(CC1)C1=CC2CCC(=O)NC=2C=C1|InChiKey: ZVNYJIZDIRKMBF-UHFFFAOYSA-N|InChi: InChI=1S/C22H25N3O4/c1-28-19-7-3-16(14-20(19)29-2)22(27)25-11-9-24(10-12-25)17-5-6-18-15(13-17)4-8-21(26)23-18/h3,5-7,13-14H,4,8-12H2,1-2H3,(H,23,26)|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO, not in water|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|References:|Hotta K, Nashimoto A, Yasumura E, Suzuki M, Azuma M, Iizumi Y, Shima D, Nabeshima R, Hiramoto M, Okada A, Sakata-Sogawa K, Tokunaga M, Ito T, Ando H, Sakamoto S, Kabe Y, Aizawa S, Imai T, Yamaguchi Y, Watanabe H, Handa H.{{Diacerein} site|{Diacerein} Calcium Channel|{Diacerein} Technical Information|{Diacerein} References|{Diacerein} supplier|{Diacerein} Autophagy} Vesnarinone suppresses TNFα mRNA expression by inhibiting valosin-containing protein.{{Estradiol} web|{Estradiol} Bacterial|{Estradiol} Biological Activity|{Estradiol} In stock|{Estradiol} supplier|{Estradiol} Epigenetic Reader Domain} Mol Pharmacol.PMID:23310954 2013 May;83(5):930-8. doi: 10.1124/mol.112.081935. Epub 2013 Feb 7. PubMed PMID: 23393163.Uchida D, Onoue T, Begum NM, Kuribayashi N, Tomizuka Y, Tamatani T, Nagai H, Miyamoto Y. Vesnarinone downregulates CXCR4 expression via upregulation of Krüppel-like factor 2 in oral cancer cells. Mol Cancer. 2009 Aug 12;8:62. doi: 10.1186/1476-4598-8-62. PubMed PMID: 19671192; PubMed Central PMCID: PMC2738650.Harada K, Supriatno, Yoshida H, Sato M. Vesnarinone inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing the expression of vascular endothelial growth factor and interleukin-8. Int J Oncol. 2005 Dec;27(6):1489-97. PubMed PMID: 16273203.Products are for research use only. Not for human use.|
