Product Name :
Z433927330
Description:
Z433927330 is a potent and selective aquaporin-7 (AQP7) inhibitor. Z433927330 is also a partial AQP3 inhibitor (IC50, ∼0.7-0.9 μm) and a potent and efficacious inhibitor of mouse AQP7 water permeability (IC50, ∼0.2 μm). Moreover, Z433927330 blocked aquaglyceroporin H2O2 permeability.
CAS:
1005883-72-6
Molecular Weight:
364.40
Formula:
C20H20N4O3
Chemical Name:
ethyl 4-(3-(4-(1H-pyrazol-1-yl)benzyl)ureido)benzoate
Smiles :
CCOC(=O)C1C=CC(=CC=1)NC(=O)NCC1C=CC(=CC=1)N1C=CC=N1
InChiKey:
KQUKHINHCUELQL-UHFFFAOYSA-N
InChi :
InChI=1S/C20H20N4O3/c1-2-27-19(25)16-6-8-17(9-7-16)23-20(26)21-14-15-4-10-18(11-5-15)24-13-3-12-22-24/h3-13H,2,14H2,1H3,(H2,21,23,26)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Z433927330 is a potent and selective aquaporin-7 (AQP7) inhibitor.{{Isatuximab} medchemexpress|{Isatuximab} Apoptosis|{Isatuximab} Biological Activity|{Isatuximab} In stock|{Isatuximab} manufacturer|{Isatuximab} Epigenetic Reader Domain} Z433927330 is also a partial AQP3 inhibitor (IC50, ∼0.{{4-Octyl itaconate} site|{4-Octyl itaconate} Keap1-Nrf2|{4-Octyl itaconate} Immunology/Inflammation|{4-Octyl itaconate} Technical Information|{4-Octyl itaconate} In Vivo|{4-Octyl itaconate} supplier} 7-0.PMID:23443926 9 μm) and a potent and efficacious inhibitor of mouse AQP7 water permeability (IC50, ∼0.2 μm). Moreover, Z433927330 blocked aquaglyceroporin H2O2 permeability.|Product information|CAS Number: 1005883-72-6|Molecular Weight: 364.40|Formula: C20H20N4O3|Synonym:|Z-433927330|Z433927330|Z 433927330|Chemical Name: ethyl 4-(3-(4-(1H-pyrazol-1-yl)benzyl)ureido)benzoate|Smiles: CCOC(=O)C1C=CC(=CC=1)NC(=O)NCC1C=CC(=CC=1)N1C=CC=N1|InChiKey: KQUKHINHCUELQL-UHFFFAOYSA-N|InChi: InChI=1S/C20H20N4O3/c1-2-27-19(25)16-6-8-17(9-7-16)23-20(26)21-14-15-4-10-18(11-5-15)24-13-3-12-22-24/h3-13H,2,14H2,1H3,(H2,21,23,26)|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|Z433927330 inhibits glycerol permeability, with an IC50 of ~0.6 µM.|References:|Sonntag Y, Gena P, Maggio A, Singh T, Artner I, Oklinski MK, Johanson U, Kjellbom P, Nieland JD, Nielsen S, Calamita G, Rützler M. Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors. J Biol Chem. 2019 May 3;294(18):7377-7387. doi: 10.1074/jbc.RA118.006083. Epub 2019 Mar 11. PMID: 30862673; PMCID: PMC6509502.Products are for research use only. Not for human use.|
