Product Name :
EHop-016
Description:
EHop-016 is a novel potent and selective inhibitor of RAC. EHop-016 inhibits Rac activity in the MDA-MB-435 metastatic cancer cells that overexpress Rac and exhibits high endogenous Rac activity. The IC(50) of 1.1 μM for Rac inhibition by EHop-016 is ~ 100-fold lower than for NSC23766. EHop-016 is specific for Rac1 and Rac3 at concentrations of < 5 μM. At higher concentrations, EHop-016 inhibits the close homolog Cdc42. EHop-016 also inhibits the Rac activity of MDA-MB-231 metastatic breast cancer cells and reduces Rac-directed lamellipodia formation in both cell lines. EHop-016 decreases Rac downstream effects of PAK1 (p21-activated kinase 1) activity and directed migration of metastatic cancer cells. EHop-016 holds promise as a targeted therapeutic agent for the treatment of metastatic cancers with high Rac activity.
CAS:
1380432-32-5
Molecular Weight:
430.55
Formula:
C25H30N6O
Chemical Name:
N4-(9-ethyl-9H-carbazol-3-yl)-N2-[3-(morpholin-4-yl)propyl]pyrimidine-2,4-diamine
Smiles :
CCN1C2=CC=C(C=C2C2=CC=CC=C12)NC1=CC=NC(NCCCN2CCOCC2)=N1
InChiKey:
AFTZZRFCMOAFCR-UHFFFAOYSA-N
InChi :
InChI=1S/C25H30N6O/c1-2-31-22-7-4-3-6-20(22)21-18-19(8-9-23(21)31)28-24-10-12-27-25(29-24)26-11-5-13-30-14-16-32-17-15-30/h3-4,6-10,12,18H,2,5,11,13-17H2,1H3,(H2,26,27,28,29)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
EHop-016 is a novel potent and selective inhibitor of RAC. EHop-016 inhibits Rac activity in the MDA-MB-435 metastatic cancer cells that overexpress Rac and exhibits high endogenous Rac activity. The IC(50) of 1.1 μM for Rac inhibition by EHop-016 is ~ 100-fold lower than for NSC23766. EHop-016 is specific for Rac1 and Rac3 at concentrations of Product information|CAS Number: 1380432-32-5|Molecular Weight: 430.55|Formula: C25H30N6O|Chemical Name: N4-(9-ethyl-9H-carbazol-3-yl)-N2-[3-(morpholin-4-yl)propyl]pyrimidine-2,4-diamine|Smiles: CCN1C2=CC=C(C=C2C2=CC=CC=C12)NC1=CC=NC(NCCCN2CCOCC2)=N1|InChiKey: AFTZZRFCMOAFCR-UHFFFAOYSA-N|InChi: InChI=1S/C25H30N6O/c1-2-31-22-7-4-3-6-20(22)21-18-19(8-9-23(21)31)28-24-10-12-27-25(29-24)26-11-5-13-30-14-16-32-17-15-30/h3-4,6-10,12,18H,2,5,11,13-17H2,1H3,(H2,26,27,28,29)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Bliretrigine} MedChemExpress|{Bliretrigine} Sodium Channel|{Bliretrigine} Technical Information|{Bliretrigine} Purity|{Bliretrigine} custom synthesis|{Bliretrigine} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Acamprosate} MedChemExpress|{Acamprosate} GABA Receptor|{Acamprosate} Purity & Documentation|{Acamprosate} In stock|{Acamprosate} custom synthesis|{Acamprosate} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23554582 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
