Product Name :
(S)-GNE-987
Description:
(S)-GNE-987 (compound 4), the GNE-987 (a chimeric BET degrader) hydroxy-proline epimer, abrogates binding to VHL and does not degrade BRD4 protein. (S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).
CAS:
2417371-71-0
Molecular Weight:
1096.31
Formula:
C56H67F2N9O8S2
Chemical Name:
(2S,4S)-1-[(2S)-2-(11-{[8-(3,5-difluoropyridin-2-yl)-4-(methanesulfonylmethyl)-15-methyl-14-oxo-8,12,15-triazatetracyclo[8.6.1.0²,⁷.0¹³,¹⁷]heptadeca-1(16),2,4,6,10,13(17)-hexaen-5-yl]formamido}undecanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
Smiles :
CN1C=C2C3=CC(CS(C)(=O)=O)=C(C=C3N(CC3=CNC(C1=O)=C32)C1=NC=C(F)C=C1F)C(=O)NCCCCCCCCCCC(=O)N[C@H](C(=O)N1C[C@@H](O)C[C@H]1C(=O)NCC1C=CC(=CC=1)C1SC=NC=1C)C(C)(C)C
InChiKey:
VTPSYVSGGUUAFN-UBCXKQDMSA-N
InChi :
InChI=1S/C56H67F2N9O8S2/c1-33-49(76-32-63-33)35-18-16-34(17-19-35)25-62-53(71)45-23-39(68)29-67(45)55(73)50(56(2,3)4)64-46(69)15-13-11-9-7-8-10-12-14-20-59-52(70)40-24-44-41(21-36(40)31-77(6,74)75)42-30-65(5)54(72)48-47(42)37(26-60-48)28-66(44)51-43(58)22-38(57)27-61-51/h16-19,21-22,24,26-27,30,32,39,45,50,60,68H,7-15,20,23,25,28-29,31H2,1-6H3,(H,59,70)(H,62,71)(H,64,69)/t39-,45-,50+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
(S)-GNE-987 (compound 4), the GNE-987 (a chimeric BET degrader) hydroxy-proline epimer, abrogates binding to VHL and does not degrade BRD4 protein.{{Sertindole} site|{Sertindole} Neuronal Signaling|{Sertindole} Technical Information|{Sertindole} Purity|{Sertindole} custom synthesis|{Sertindole} Autophagy} (S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.{{Lacutamab} site|{Lacutamab} Biological Activity|{Lacutamab} In stock|{Lacutamab} manufacturer|{Lacutamab} Autophagy} 9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).PMID:24635174 |Product information|CAS Number: 2417371-71-0|Molecular Weight: 1096.31|Formula: C56H67F2N9O8S2|Chemical Name: (2S,4S)-1-[(2S)-2-(11-{[8-(3,5-difluoropyridin-2-yl)-4-(methanesulfonylmethyl)-15-methyl-14-oxo-8,12,15-triazatetracyclo[8.6.1.0²,⁷.0¹³,¹⁷]heptadeca-1(16),2,4,6,10,13(17)-hexaen-5-yl]formamido}undecanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide|Smiles: CN1C=C2C3=CC(CS(C)(=O)=O)=C(C=C3N(CC3=CNC(C1=O)=C32)C1=NC=C(F)C=C1F)C(=O)NCCCCCCCCCCC(=O)N[C@H](C(=O)N1C[C@@H](O)C[C@H]1C(=O)NCC1C=CC(=CC=1)C1SC=NC=1C)C(C)(C)C|InChiKey: VTPSYVSGGUUAFN-UBCXKQDMSA-N|InChi: InChI=1S/C56H67F2N9O8S2/c1-33-49(76-32-63-33)35-18-16-34(17-19-35)25-62-53(71)45-23-39(68)29-67(45)55(73)50(56(2,3)4)64-46(69)15-13-11-9-7-8-10-12-14-20-59-52(70)40-24-44-41(21-36(40)31-77(6,74)75)42-30-65(5)54(72)48-47(42)37(26-60-48)28-66(44)51-43(58)22-38(57)27-61-51/h16-19,21-22,24,26-27,30,32,39,45,50,60,68H,7-15,20,23,25,28-29,31H2,1-6H3,(H,59,70)(H,62,71)(H,64,69)/t39-,45-,50+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
