Product Name :
NGB 2904
Description:
NGB 2904 is an orally active and selective dopamine (DA) D3 receptor antagonist. NGB 2904 can be used for the research of cocaine addiction.
CAS:
189060-98-8
Molecular Weight:
530.92
Formula:
C28H30Cl3N3O
Chemical Name:
N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}-9H-fluorene-2-carboxamide hydrochloride
Smiles :
Cl.O=C(NCCCCN1CCN(CC1)C1=CC=CC(Cl)=C1Cl)C1=CC2CC3=CC=CC=C3C=2C=C1
InChiKey:
PFIWYJNBKGCVFM-UHFFFAOYSA-N
InChi :
InChI=1S/C28H29Cl2N3O.ClH/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24;/h1-2,5-11,19H,3-4,12-18H2,(H,31,34);1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NGB 2904 is an orally active and selective dopamine (DA) D3 receptor antagonist. NGB 2904 can be used for the research of cocaine addiction.|Product information|CAS Number: 189060-98-8|Molecular Weight: 530.{{Nivolumab} web|{Nivolumab} Immunology/Inflammation|{Nivolumab} Protocol|{Nivolumab} In Vivo|{Nivolumab} supplier|{Nivolumab} Epigenetic Reader Domain} 92|Formula: C28H30Cl3N3O|Chemical Name: N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}-9H-fluorene-2-carboxamide hydrochloride|Smiles: Cl.O=C(NCCCCN1CCN(CC1)C1=CC=CC(Cl)=C1Cl)C1=CC2CC3=CC=CC=C3C=2C=C1|InChiKey: PFIWYJNBKGCVFM-UHFFFAOYSA-N|InChi: InChI=1S/C28H29Cl2N3O.ClH/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24;/h1-2,5-11,19H,3-4,12-18H2,(H,31,34);1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|NGB 2904 (0.1~5 mg/kg; i.p.) significantly loweres the break-point for cocaine self-administration behavior reinforced under progressive-ratio conditions and significantly inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats extinguished from daily cocaine self-administration.{{Methazolamide} web|{Methazolamide} Carbonic Anhydrase|{Methazolamide} Technical Information|{Methazolamide} Formula|{Methazolamide} custom synthesis|{Methazolamide} Cancer} NGB 2904 (0~10 mg/kg; i.PMID:23916866 p.) administered 30 min prior to the beginning of daily cocaine self-administration sessions has no significant effect on cocaine self-administration behavior at a unit cocaine reinforcement dose of 0.5 mg/kg/infusion compared to vehicle-treated animals. NGB 2904 (0.1 and 1 mg/kg) pretreatment significantly inhibits the enhanced brain stimulation reward produced by 2 mg/kg, but not by 10 mg/kg, of cocaine. NGB 2904 pretreatment produces a significant attenuation of this cocaine-triggered reinstatement of drug-seeking.|Products are for research use only. Not for human use.|
