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Product Name :
E-4031

Description:
E4031 selectively blocks hERG K+ channels. E4031 inhibits the rapid delayed-rectifier K+ current (IKr) and reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na+ or Ca2+ inward currents. E4031 is a class III antiarrhythmic agent.

CAS:
113559-13-0

Molecular Weight:
474.44

Formula:
C21H29Cl2N3O3S

Chemical Name:
N-(4-{1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl}phenyl)methanesulfonamide dihydrochloride

Smiles :
Cl.{{Nicotinamide N-Methyltransferase/NNMT Protein, Human (His)} web|{Nicotinamide N-Methyltransferase/NNMT Protein, Human (His)} Biological Activity|{Nicotinamide N-Methyltransferase/NNMT Protein, Human (His)} References|{Nicotinamide N-Methyltransferase/NNMT Protein, Human (His)} custom synthesis|{Nicotinamide N-Methyltransferase/NNMT Protein, Human (His)} Epigenetics} Cl.CC1=CC=CC(CCN2CCC(CC2)C(=O)C2C=CC(=CC=2)NS(C)(=O)=O)=N1

InChiKey:
ZQBNWMFBOSOOLX-UHFFFAOYSA-N

InChi :
InChI=1S/C21H27N3O3S.2ClH/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27;;/h3-9,18,23H,10-15H2,1-2H3;2*1H

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥360 days if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
E4031 selectively blocks hERG K+ channels. E4031 inhibits the rapid delayed-rectifier K+ current (IKr) and reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na+ or Ca2+ inward currents. E4031 is a class III antiarrhythmic agent.|Product information|CAS Number: 113559-13-0|Molecular Weight: 474.44|Formula: C21H29Cl2N3O3S|Chemical Name: N-(4-{1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl}phenyl)methanesulfonamide dihydrochloride|Smiles: Cl.Cl.CC1=CC=CC(CCN2CCC(CC2)C(=O)C2C=CC(=CC=2)NS(C)(=O)=O)=N1|InChiKey: ZQBNWMFBOSOOLX-UHFFFAOYSA-N|InChi: InChI=1S/C21H27N3O3S.{{Nicotinamide riboside} site|{Nicotinamide riboside} Metabolic Enzyme/Protease|{Nicotinamide riboside} Technical Information|{Nicotinamide riboside} Data Sheet|{Nicotinamide riboside} manufacturer|{Nicotinamide riboside} Epigenetic Reader Domain} 2ClH/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27;;/h3-9,18,23H,10-15H2,1-2H3;2*1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24140575 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Author: nucleoside analogue