Product Name :
Modipafant
Description:
Modipafant (UK-80067), the (+)-enantiomer of UK-74505, is a potent, orally active, and selective platelet-activating factor (PAF) antagonist. Modipafant exhibits approximately double the intrinsic potency of UK-74505.
CAS:
122957-06-6
Molecular Weight:
605.09
Formula:
C34H29ClN6O3
Chemical Name:
ethyl (4R)-4-(2-chlorophenyl)-6-methyl-2-(4-{2-methyl-1H-imidazo[4,5-c]pyridin-1-yl}phenyl)-5-[(pyridin-2-yl)carbamoyl]-1,4-dihydropyridine-3-carboxylate
Smiles :
CCOC(=O)C1[C@@H](C(C(=O)NC2=CC=CC=N2)=C(C)NC=1C1C=CC(=CC=1)N1C2=CC=NC=C2N=C1C)C1=CC=CC=C1Cl
InChiKey:
ODRYSCQFUGFOSU-SSEXGKCCSA-N
InChi :
InChI=1S/C34H29ClN6O3/c1-4-44-34(43)31-30(24-9-5-6-10-25(24)35)29(33(42)40-28-11-7-8-17-37-28)20(2)38-32(31)22-12-14-23(15-13-22)41-21(3)39-26-19-36-18-16-27(26)41/h5-19,30,38H,4H2,1-3H3,(H,37,40,42)/t30-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Modipafant (UK-80067), the (+)-enantiomer of UK-74505, is a potent, orally active, and selective platelet-activating factor (PAF) antagonist. Modipafant exhibits approximately double the intrinsic potency of UK-74505.|Product information|CAS Number: 122957-06-6|Molecular Weight: 605.09|Formula: C34H29ClN6O3|Chemical Name: ethyl (4R)-4-(2-chlorophenyl)-6-methyl-2-(4-{2-methyl-1H-imidazo[4,5-c]pyridin-1-yl}phenyl)-5-[(pyridin-2-yl)carbamoyl]-1,4-dihydropyridine-3-carboxylate|Smiles: CCOC(=O)C1[C@@H](C(C(=O)NC2=CC=CC=N2)=C(C)NC=1C1C=CC(=CC=1)N1C2=CC=NC=C2N=C1C)C1=CC=CC=C1Cl|InChiKey: ODRYSCQFUGFOSU-SSEXGKCCSA-N|InChi: InChI=1S/C34H29ClN6O3/c1-4-44-34(43)31-30(24-9-5-6-10-25(24)35)29(33(42)40-28-11-7-8-17-37-28)20(2)38-32(31)22-12-14-23(15-13-22)41-21(3)39-26-19-36-18-16-27(26)41/h5-19,30,38H,4H2,1-3H3,(H,37,40,42)/t30-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Luspatercept} MedChemExpress|{Luspatercept} Stem Cell/Wnt|{Luspatercept} Biological Activity|{Luspatercept} In stock|{Luspatercept} manufacturer|{Luspatercept} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{Diacerein} site|{Diacerein} Interleukin Related|{Diacerein} Protocol|{Diacerein} Formula|{Diacerein} custom synthesis|{Diacerein} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32965900 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|when preincubated with rabbit platelets, the potency of antagonizing PAF induced aggregation increased markedly when preincubation time with Modipafant was increased from 2 min (IC50=5.6 nM) to 60 min (IC50=0.34 nM).|Products are for research use only. Not for human use.|
