Product Name :
NMS-P515
Description:
NMS-P515 is a potent, orally active and stereospecific PARP-1 inhibitor, with a Kd of 16 nM and an IC50 of 27 nM (in Hela cells). Anti-tumor activity.
CAS:
1262395-13-0
Molecular Weight:
355.47
Formula:
C21H29N3O2
Chemical Name:
(1S)-2-(1-cyclohexylpiperidin-4-yl)-1-methyl-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide
Smiles :
C[C@H]1C2=CC=CC(C(N)=O)=C2C(=O)N1C1CCN(CC1)C1CCCCC1
InChiKey:
OYGLTKXMFGWXJT-AWEZNQCLSA-N
InChi :
InChI=1S/C21H29N3O2/c1-14-17-8-5-9-18(20(22)25)19(17)21(26)24(14)16-10-12-23(13-11-16)15-6-3-2-4-7-15/h5,8-9,14-16H,2-4,6-7,10-13H2,1H3,(H2,22,25)/t14-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{MS170} web|{MS170} Akt|{MS170} Technical Information|{MS170} Data Sheet|{MS170} manufacturer|{MS170} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Cediranib} MedChemExpress|{Cediranib} PDGFR|{Cediranib} Technical Information|{Cediranib} Description|{Cediranib} custom synthesis|{Cediranib} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NMS-P515 is a potent, orally active and stereospecific PARP-1 inhibitor, with a Kd of 16 nM and an IC50 of 27 nM (in Hela cells). Anti-tumor activity.|Product information|CAS Number: 1262395-13-0|Molecular Weight: 355.47|Formula: C21H29N3O2|Chemical Name: (1S)-2-(1-cyclohexylpiperidin-4-yl)-1-methyl-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide|Smiles: C[C@H]1C2=CC=CC(C(N)=O)=C2C(=O)N1C1CCN(CC1)C1CCCCC1|InChiKey: OYGLTKXMFGWXJT-AWEZNQCLSA-N|InChi: InChI=1S/C21H29N3O2/c1-14-17-8-5-9-18(20(22)25)19(17)21(26)24(14)16-10-12-23(13-11-16)15-6-3-2-4-7-15/h5,8-9,14-16H,2-4,6-7,10-13H2,1H3,(H2,22,25)/t14-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32448942 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|NMS-P515 (80 mg/kg, orally daily for 12 days) exhibits potent antitumor activity in mouse models based pancreatic cancer.|Products are for research use only. Not for human use.|
