Product Name :
PGE2 CLIA kit
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Store all components at 4°C, except standard and conjugate at -20°C.
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Validated in numerous sample matricesResults in just 3 hoursSensitive to 6.03 pg/mlResults from up to 36 samples in duplicate per plate The PGE2 CLIA kit is a sensitive chemiluminescent competitive enzyme immunoassay kit for the quantitative determination of PGE2 in biological fluids from any species.{{95809-78-2} MedChemExpress|{95809-78-2} Purity & Documentation|{95809-78-2} Description|{95809-78-2} supplier} Prostaglandin E2 (PGE2) is an extensively studied prostaglandin owing to its predominance in inflammation, cancer, atherosclerosis, autoimmune disease, and sepsis. Oxidation of arachidonic acid by prostaglandin synthases (COX-1 and COX-2) produces prostaglandin H2 (PGH2), which is further metabolized by PGE synthases into its major product, PGE2. PGE2 mediates autocrine and paracrine signaling by binding to G-protein coupled receptors (EP1, EP2, EP3, EP4) on the cell surface, functioning to modulate phospholipase C and adenylate cyclase activity.{{477775-14-7} MedChemExpress|{477775-14-7} Technical Information|{477775-14-7} Description|{477775-14-7} manufacturer} PGE2 has been of great interest as a therapeutic target, either by modulation of its synthesis by COX inhibitors (NSAIDS) or by modulation of its receptors by downregulation or binding antagonists.PMID:28613711 PGE2 production in a variety of tissues has been shown to modulate numerous physiological processes including natriuresis in the kidney, smooth muscle elasticity in the vasculature, and the inflammatory response to damaged tissues by monocytes and macrophages. PGE2 CLIA kit Kit graph PGE2 CLIA kit Kit graph
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| Alternative Name Prostaglandin E2 | Application Chemiluminescence | Application Notes For the quantitative determination of PGE2 in culture supernatants, serum, saliva, urine, and whole blood from any species. | Assay Time 3 hours | Contents White GxM IgG Microtiter plate, Conjugate, Antibody, Assay buffer, Wash buffer concentrate, Standard, CLIA Substrate | Sensitivity 6.03 pg/ml (range 7.81 – 1,000 pg/ml) | Species Reactivity Species independent
