Product Name :
WNK-IN-11 D3
Description:
WNK-IN-11 D3 is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11 D3 is effective at regulating cardiovascular homeostasis.
CAS:
2123483-49-6
Molecular Weight:
465.41
Formula:
C21H21Cl2N5OS
Chemical Name:
4-(5-chloro-4-4-[(4-chlorophenyl)methyl]piperazine-1-carbonylpyridin-2-yl)-N-(²H₃)methyl-1,3-thiazol-2-amine
Smiles :
[2H]C([2H])([2H])NC1=NC(=CS1)C1=CC(C(=O)N2CCN(CC3C=CC(Cl)=CC=3)CC2)=C(Cl)C=N1
InChiKey:
MVXAYIXYYOVALX-FIBGUPNXSA-N
InChi :
InChI=1S/C21H21Cl2N5OS/c1-24-21-26-19(13-30-21)18-10-16(17(23)11-25-18)20(29)28-8-6-27(7-9-28)12-14-2-4-15(22)5-3-14/h2-5,10-11,13H,6-9,12H2,1H3,(H,24,26)/i1D3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Seribantumab Protein Tyrosine Kinase/RTK
Shelf Life:
≥12 months if stored properly.Curcumin Autophagy
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33148628
Additional information:
WNK-IN-11 D3 is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11 D3 is effective at regulating cardiovascular homeostasis.|Product information|CAS Number: 2123483-49-6|Molecular Weight: 465.41|Formula: C21H21Cl2N5OS|Chemical Name: 4-(5-chloro-4-4-[(4-chlorophenyl)methyl]piperazine-1-carbonylpyridin-2-yl)-N-(²H₃)methyl-1,3-thiazol-2-amine|Smiles: [2H]C([2H])([2H])NC1=NC(=CS1)C1=CC(C(=O)N2CCN(CC3C=CC(Cl)=CC=3)CC2)=C(Cl)C=N1|InChiKey: MVXAYIXYYOVALX-FIBGUPNXSA-N|InChi: InChI=1S/C21H21Cl2N5OS/c1-24-21-26-19(13-30-21)18-10-16(17(23)11-25-18)20(29)28-8-6-27(7-9-28)12-14-2-4-15(22)5-3-14/h2-5,10-11,13H,6-9,12H2,1H3,(H,24,26)/i1D3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|WNK-IN-11 D3 (1.5 mg/kg; p.o.) shows an improved rat PK profile, including lower clearance, improvement in absolute oral exposure, and a 2-fold improvement in oral bioavailability. WNK-IN-11 D3 (30 mg/kg; p.o.) shows significant reductions in systolic blood pressure (SBP) vs untreated mice. WNK-IN-11 D3 (0~100 mg/kg; p.o.) induces dose dependent diuresis, natriuresis, and kaliuresis, from 10 to 100 mg/kg. WNK-IN-11 D3 shows trends toward reduction of blood pressure, stroke volume, and total peripheral resistance, while increasing heart rate. WNK-IN-11 D3 shows efficacy in rodent models of hypertension and volume overload.|Products are for research use only. Not for human use.|
