3.82 (2.20, 5.44) 6.31 (3.09, 9.53) 2.32 (1.06, 3.58) 5.03 (2.63, 7.43) 2.38 (0.97, 3.79)

3.82 (2.20, 5.44) 6.31 (3.09, 9.53) 2.32 (1.06, 3.58) 5.03 (2.63, 7.43) 2.38 (0.97, 3.79) 3.09 (1.21, 4.97) 3.20 (1.29, 5.11) 5.47 (1.31, 9.63) 2.19 (0.94, 3.44) 7.54 (3.56, 11.52) 3.05 (0.0, 7.18) 3.30 (1.61, 4.99) 2.36 (0.48, 4.24) 7.49 (1.99, 12.99) 3.10 (1.47, 4.73) 2.54 (0.55, 4.53) 7.73 (2.24, 13.22) 3.24 (0.88, 5.60) 2.57 (1.08, 4.06) 7.24 (2.55, 11.93) 2.39 (0.12, 4.66) 2.91 (1.40, 4.42) 7.37 (2.62, 12.12) No. Deaths 4561 307 588 1055 2611 2179 2382 3075 1486 4326 235 581 3980 967 3594 2124 2437 2517 2044 1754 1838 969 2084 2107 370 2406 1140 1015 2321 1172 1068 1253 2026 1282 782 2483 1296 10-Year Follow-Up Person Years 12,2929.5 26,328.9 34,384.4 30,701.2 31,515.0 61,942.9 60,986.6 95,153.6 27,775.8 11,9076.3 3853.2 27,295.1 95,634.3 38,361.7 84,567.8 36,215.8 86,713.7 51,989.5 70,940.0 51,138.8 51,850.1 19,940.6 84,441.7 26,179.9 12,307.9 67,844.4 39,098.5 15,986.6 67,964.7 38,567.3 16,397.4 34,843.8 67,480.9 20,604.8 28,603.1 73,860.2 20,466.2 Mortality Rate (per 100) (95 CI) 3.71 (2.63, 4.79) 1.17 (0.00, 2.47) 1.71 (0.33, 3.09) 3.44 (1.37, 5.51) 8.28 (5.10, 11.46) 3.52 (2.04, 5.00) 3.91 (2.34, 5.48) 3.23 (2.09, 4.37) 5.35 (2.63, 8.07) 3.63 (2.55, 4.71) 6.10 (0.00, 13.90) 2.13 (0.40, 3.86) 4.16 (2.87, 5.45) 2.52 (0.93, 4.11) 4.25 (2.86, 5.64) 5.86 (3.37, 8.35) 2.81 (1.69, 3.93) 4.84 (2.95, 6.73) 2.88 (1.63, 4.13) 3.43 (1.82, 5.04) 3.54 (1.92, 5.16) 4.86 (1.80, 7.92) 2.47 (1.41, 3.53) 8.05 (4.61, 11.49) 3.01 (0.0, 6.07) 3.55 (2.13, 4.97) 2.92 (1.23, 4.61) 6.35 (2.44, 10.26) 3.42 (2.03, 4.81) 3.04 (1.30, 4.78) 6.51 (2.60, 10.42) 3.60 (1.61, 5.59) 3.00 (1.69, 4.31) 6.22 (2.81, 9.63) 2.73 (0.81, 4.65) 3.36 (2.04, 4.68) 6.33 (2.88, 9.78)Overall
3.82 (2.20, 5.44) 6.31 (3.09, 9.53) 2.32 (1.06, 3.58) 5.03 (2.63, 7.43) 2.38 (0.97, 3.79) 3.09 (1.21, 4.97) 3.20 (1.29, 5.11) 5.47 (1.31, 9.63) 2.19 (0.94, 3.44) 7.54 (3.56, 11.52) 3.05 (0.0, 7.18) 3.30 (1.61, 4.99) 2.36 (0.48, 4.24) 7.49 (1.99, 12.99) 3.10 (1.47, 4.73) 2.54 (0.55, 4.53) 7.73 (2.24, 13.22) 3.24 (0.88, 5.60) 2.57 (1.08, 4.06) 7.24 (2.55, 11.93) 2.39 (0.12, 4.66) 2.91 (1.40, 4.42) 7.37 (2.62, 12.12) No. Deaths 4561 307 588 1055 2611 2179 2382 3075 1486 4326 235 581 3980 967 3594 2124 2437 2517 2044 1754 1838 969 2084 2107 370 2406 1140 1015 2321 1172 1068 1253 2026 1282 782 2483 1296 10-Year Follow-Up Person Years 12,2929.5 26,328.9 34,384.4 30,701.2 31,515.0 61,942.9 60,986.6 95,153.6 27,775.8 11,9076.3 3853.2 27,295.1 95,634.3 38,361.7 84,567.8 36,215.8 86,713.7 51,989.5 70,940.0 51,138.8 51,850.1 19,940.6 84,441.7 26,179.9 12,307.9 67,844.4 39,098.5 15,986.6 67,964.7 38,567.3 16,397.4 34,843.8 67,480.9 20,604.8 28,603.1 73,860.2 20,466.2 Mortality Rate (per 100) (95 CI) 3.71 (2.63, 4.79) 1.17 (0.00, 2.47) 1.71 (0.33, 3.09) 3.44 (1.37, 5.51) 8.28 (5.10, 11.46) 3.52 (2.04, 5.00) 3.91 (2.34, 5.48) 3.23 (2.09, 4.37) 5.35 (2.63, 8.07) 3.63 (2.55, 4.71) 6.10 (0.00, 13.90) 2.13 (0.40, 3.86) 4.16 (2.87, 5.45) 2.52 (0.93, 4.11) 4.25 (2.86, 5.64) 5.86 (3.37, 8.35) 2.81 (1.69, 3.93) 4.84 (2.95, 6.73) 2.88 (1.63, 4.13) 3.43 (1.82, 5.04) 3.54 (1.92, 5.16) 4.86 (1.80, 7.92) 2.47 (1.41, 3.53) 8.05 (4.61, 11.49) 3.01 (0.0, 6.07) 3.55 (2.13, 4.97) 2.92 (1.23, 4.61) 6.35 (2.44, 10.26) 3.42 (2.03, 4.81) 3.04 (1.30, 4.78) 6.51 (2.60, 10.42) 3.60 (1.61, 5.59) 3.00 (1.69, 4.31) 6.22 (2.81, 9.63) 2.73 (0.81, 4.65) 3.36 (2.04, 4.68) 6.33 (2.88, 9.78)Overall 2779 Age at entry 50 y/o 169 509 y/o 322 609 y/o 601 70 y/o 1687 Sex Female 1337 Male 1442 History of cancer No 1867 Yes 912 History of PVD No 2635 Yes 144 History of hypertension No 381 Yes 2398 Use of antihypertensive drugs No 648 Yes 2131 History of hyperlipidemia No 1478 Yes 1301 Use of antihyperlipidemic drugs No 1685 Yes 1094 HbA1c Normal (7) 1034 IEM-1460 Autophagy Abnormal ( 7) 1081 Missing 664 Creatinine Normal 1191 Abnormal 1379 Missing 209 Total cholesterol Normal (200) 1460 Abnormal ( 200) 606 Missing 713 Triglyceride Normal (150) 1392 Abnormal ( 150) 626 Missing 761 LDL Normal (100) 720 Abnormal ( 100) 1143 Missing 916 HDL Normal 424 Abnormal 1430 MissingJ. Clin. Med. 2021, 10,6 ofTable 1. Cont. 7-Year Follow-Up Variables No. Deaths Person Years Mortality Rate (per 100) (95 CI) 2.45 (0.88, 4.02) 3.17 (1.01, 5.33) 6.64 (2.58, 10.70) No. Deaths 10-Year Follow-Up Person Years Mortality Rate (per 100) (95 CI)LDL /HDL ratio Normal Abnormal Missing928 82637,921.2 26,064.1 15,441.1737 136858,961.9 37,433.1 26,534.2.95 (1.56, 4.34) 3.65 (1.71, 5.59) 5.49 (2.67, 8.31)male 40,PVD: peripheral vascular disease; normal creatinine level: male 1.27, female 1.13 dL; Abnormal HDL level: female 50 dL; abnormal LDL /HDL ratio: male 3.55, female 3.22.3.2. Factors and Coefficients of Prediction Models for All-Cause Mortality Before the Cox regression analysis, our data did not violate the assumption of proportional hazards according to the graphic method with Schoenfeld residuals over time. Taking HbA1c as an example, the three Bafilomycin C1 Purity & Documentation categories (normal, abnormal, and missing) were parallel to each other and independent of time (Supplementary Figure S3A for 7 years and S3B for 10 years). First, parsimonious multivariable Cox regression models were developed by stepwise selection and AIC criteria (Supplementary Table S4.