Ia genome. N Engl J Med. 2009;361(11):1058066. six. Sen R, Baltimore D. Inducibility of kappa immunoglobulin enhancer-binding protein Nf-B by a posttranslational mechanism. Cell. 1986;47(six):92128. 7. La Rosa FA, Pierce JW, Sonenshein GE. Differential regulation of your c-myc oncogene promoter by the NF-B rel household of transcription elements. Mol Cell Biol. 1994;14(2):1039044. 8. Guttridge DC, Albanese C, Reuther JY, Pestell RG, Baldwin AS Jr. NF-B controls cell growth and differentiation via transcriptional regulation of cyclin D1. Mol Cell Biol. 1999;19(eight):5785799. 9. Duckett CS. Apoptosis and NF-B: the FADD connection. J Clin Invest. 2002;109(5):57980. 10. Karin M, Greten FR. NF-B: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 2005;five(10):74959. 11. Karin M. Nuclear factor-B in cancer improvement and progression. Nature. 2006;441(7092):43136. 12. Pikarsky E, et al. NF-B functions as a tumour promoter in inflammation-associated cancer. Nature. 2004;431(7007):46166. 13. Guzman ML, et al. Nuclear factor-B is constitutively activated in primitive human acute myelogenous leukemia cells.Halofuginone Blood. 2001;98(8):2301307. 14. Guzman ML, et al. Preferential induction of apoptosis for major human leukemic stem cells. Proc Natl Acad Sci U S A. 2002;99(25):162206225. 15. Frelin C, et al. Targeting NF-B activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells. Blood. 2005;105(two):80411. 16. Carvalho G, et al. Inhibition of NEMO, the regulatory subunit of the IKK complex, induces apoptosis in high-risk myelodysplastic syndrome and acute myeloid leukemia.Iscalimab Oncogene. 2007;26(16):2299307. 17. Guzman ML, et al. An orally bioavailable parthe-Acknowledgments We thank T. Kitamura for the Plat-E packaging cells; H. Nakauchi and M. Onodera for the pGCDNsam-IRES-EGFP retroviral vector; R. Ono and T. Nosaka for the MLL-ENL cDNA; I. Kitabayashi for the MOZ-TIF2 cDNA; W. Hahn for the pBabe-GFP and pBabeGFP-IB-SR; and H. Alg and R.M. Schmid for providing the Rela-floxed mice. This function was supported by a Grant-in-Aid for Scientific Research A (KAKENHI 12020240) in the Ministry of Education, Culture, Sports, Science and Technology of Japan. Received for publication December 3, 2012, and accepted in revised form October 17, 2013. Address correspondence to: Mineo Kurokawa, Division of Hematology and Oncology, Graduate College of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.PMID:23453497 Telephone: 81.three.5800.9092; Fax: 81.three.5840.8667; E-mail: [email protected]. Alg H, et al. Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis. J Clin Invest. 2007;117(6):1490501. 33. Beg AA, Finco TS, Nantermet PV, Baldwin AS Jr. Tumor necrosis factor and interleukin-1 result in phosphorylation and loss of IB: a mechanism for NF-B activation. Mol Cell Biol. 1993;13(6):3301310. 34. DeNardo DG, Coussens LM. Inf lammation and breast cancer. Balancing immune response: crosstalk amongst adaptive and innate immune cells in the course of breast cancer progression. Breast Cancer Res. 2007;9(four):212. 35. McLean MH, et al. The inflammatory microenvironment in colorectal neoplasia. PLoS One particular. 2011; six(1):e15366. 36. Charles KA, et al. The tumor-promoting actions of TNF- involve TNFR1 and IL-17 in ovarian cancer in mice and humans. J Clin Invest. 2009; 119(10):3011023. 37. Moore RJ, et al. Mice deficient in.
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