Product Name :
Disitamab vedotin
Description:
Disitamab vedotin (RC48) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) conjugated via a cleavable linker to the cytotoxic agent Monomethyl auristatin E (MMAE). Disitamab vedotin enhances antitumor immunity.
CAS:
2136633-23-1
Molecular Weight:
Formula:
Chemical Name:
Disitamab vedotin
Smiles :
InChiKey:
InChi :
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Riboflavin} web|{Riboflavin} Anti-infection|{Riboflavin} Purity & Documentation|{Riboflavin} Formula|{Riboflavin} custom synthesis|{Riboflavin} Autophagy}
Additional information:
Disitamab vedotin (RC48) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) conjugated via a cleavable linker to the cytotoxic agent Monomethyl auristatin E (MMAE).{{Crenezumab} web|{Crenezumab} Neuronal Signaling|{Crenezumab} Technical Information|{Crenezumab} In stock|{Crenezumab} custom synthesis|{Crenezumab} Autophagy} Disitamab vedotin enhances antitumor immunity.PMID:23460641 |Product information|CAS Number: 2136633-23-1|Synonym:|RC48|Chemical Name: Disitamab vedotin|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|The antibody part was a humanized monoclonal antibody targeting HER2, the small molecule toxin was monomethyl auristatin E (MMAE), a synthetic antineoplastic agent. A protease cleavable linker covalently attached MMAE to the antibody|References:|Jiang J, et al. Preclinical safety profile of disitamab vedotin：a novel anti-HER2 antibody conjugated with MMAE. Toxicol Lett. 2020;324:30-37.Deeks ED. Disitamab Vedotin: First Approval. Drugs. 2021;81(16):1929-1935.Products are for research use only. Not for human use.|
