Product Name :
Polydatin(Piceid)
Description:
Polydatin (Piceid), extracted from the roots of Polygonum cuspidatum Sieb, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.
CAS:
27208-80-6
Molecular Weight:
390.38
Formula:
C20H22O8
Chemical Name:
(2S, 3R, 4S, 5S, 6R)-2-[3-Hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3, 4, 5-triol
Smiles :
OC[C@H]1O[C@@H](OC2C=C(O)C=C(C=2)/C=C/C2C=CC(O)=CC=2)[C@H](O)[C@@H](O)[C@@H]1O
InChiKey:
HSTZMXCBWJGKHG-CUYWLFDKSA-N
InChi :
InChI=1S/C20H22O8/c21-10-16-17(24)18(25)19(26)20(28-16)27-15-8-12(7-14(23)9-15)2-1-11-3-5-13(22)6-4-11/h1-9,16-26H,10H2/b2-1+/t16-,17-,18+,19-,20-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Topiroxostat} medchemexpress|{Topiroxostat} Xanthine Oxidase|{Topiroxostat} Biological Activity|{Topiroxostat} In Vivo|{Topiroxostat} supplier|{Topiroxostat} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Polydatin (Piceid), extracted from the roots of Polygonum cuspidatum Sieb, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.|Product information|CAS Number: 27208-80-6|Molecular Weight: 390.38|Formula: C20H22O8|Synonym:|3, 4, 5-Tsg|3, 4, 5-Trihydroxystilbene-3-beta-monoglucoside|Chemical Name: (2S, 3R, 4S, 5S, 6R)-2-[3-Hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3, 4, 5-triol|Smiles: OC[C@H]1O[C@@H](OC2C=C(O)C=C(C=2)/C=C/C2C=CC(O)=CC=2)[C@H](O)[C@@H](O)[C@@H]1O|InChiKey: HSTZMXCBWJGKHG-CUYWLFDKSA-N|InChi: InChI=1S/C20H22O8/c21-10-16-17(24)18(25)19(26)20(28-16)27-15-8-12(7-14(23)9-15)2-1-11-3-5-13(22)6-4-11/h1-9,16-26H,10H2/b2-1+/t16-,17-,18+,19-,20-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 78 mg/mL(199.{{Amifampridine} site|{Amifampridine} Potassium Channel|{Amifampridine} Protocol|{Amifampridine} Formula|{Amifampridine} supplier|{Amifampridine} Autophagy} 8 mM).PMID:24268253 Water: Insoluble.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Polydatin, known as a PLA2 inhibitor, reduces Phospholipase A2 (PLA2) activity and sPLA2-IIA mRNA expression and mitigates LPS-induced lung injury by increasing increased Clara cell secretory protein (CCSP) expression.|In Vivo:|Pretreatment with Polydatin (15, 45, and 100 mg/kg) dose-dependently reduces sepsis-induced mortality and lung injury in cecal ligation and puncture (CLP-)induced sepsis mice through inhibiting CLP-induced serum tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) production, lung cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase isoform (iNOS) protein expressions and NF-kappaB activation. LD50: Mice 1g/kg (i.p.)|References:|Li XH, et al. Mediators Inflamm, 2013, 2013, 354087.Shiyu S, et al. BMC Cell Biol, 2011, 25, 12:31.Products are for research use only. Not for human use.|
