F461.3B

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Product Name :
F461.3B
Clone ID/Product Name: F461.3B;
Available to For-Profits: Yes;
Alternate Antibody Name: ;
Gene Symbol: N;
Ab Isotype: MIgG1;
Gene Name: ;
Antibody Registry ID: AB_528409 ;
Uniprot ID: P07207 ;
Entrez Gene ID: 31293 ;
Clonality: Monoclonal;
Immunogen: Recombinant fusion protein containing the EGF repeats #5-7;
Immunogen Sequence: Partial protein;
Myeloma Strain: Ag8;
Epitope Mapped: Yes;
Antigen Name: Notch, extracellular domain, EGF repeats #5-7;
Epitope Location or Sequence: extracellular domain, EGF repeats #5-7 [see depositor notes];
Alternate Antigen Name: ;
Deposit Date: 5/2/2000;
Antigen Molecular Weight: Predicted: 289 kDa; Apparent: 300 kDa and lower MW N-terminal fragment, resulting from proteolysis.;
Antigen Sequence: ;
Depositor Institution: Harvard Medical School;
Antigen Species: Drosophila;
Depositor Notes: This antibody was generated against the extracellular domain of Notch containing the EGF repeats # 5-7;
Host Species: mouse;
Hybridoma Cells Available : Yes;
Confirmed Species Reactivity: Drosophila;
Additional Information: The Neurogenic locus Notch protein functions as a transmembrane receptor for membrane-bound ligands Delta and Serrate to regulate neurodevelopment. Upon ligand activation, the intracellular domain is released from the cell membrane, and forms a transcriptional activator complex with the Suppressor of hairless protein.;
Predicted Species Reactivity: ;
Human Protein Atlas: ;
Additional Characterization: ;
Recommended Applications: Immunofluorescence, Western Blot;

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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