Product Name :
ALS-8112
Description:
ALS-8112 is a potent and selective respiratory syncytial virus (RSV) polymerase inhibitor. The 5′-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC50 of 0.02 μM.
CAS:
1445379-92-9
Molecular Weight:
293.68
Formula:
C10H13ClFN3O4
Chemical Name:
4-amino-1-[(2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one
Smiles :
NC1C=CN([C@@H]2O[C@@](CO)(CCl)[C@@H](O)[C@H]2F)C(=O)N=1
InChiKey:
AWSRKKBIPSQHOJ-IBCQBUCCSA-N
InChi :
InChI=1S/C10H13ClFN3O4/c11-3-10(4-16)7(17)6(12)8(19-10)15-2-1-5(13)14-9(15)18/h1-2,6-8,16-17H,3-4H2,(H2,13,14,18)/t6-,7+,8-,10-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ALS-8112 is a potent and selective respiratory syncytial virus (RSV) polymerase inhibitor. The 5′-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC50 of 0.02 μM.|Product information|CAS Number: 1445379-92-9|Molecular Weight: 293.68|Formula: C10H13ClFN3O4|Chemical Name: 4-amino-1-[(2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one|Smiles: NC1C=CN([C@@H]2O[C@@](CO)(CCl)[C@@H](O)[C@H]2F)C(=O)N=1|InChiKey: AWSRKKBIPSQHOJ-IBCQBUCCSA-N|InChi: InChI=1S/C10H13ClFN3O4/c11-3-10(4-16)7(17)6(12)8(19-10)15-2-1-5(13)14-9(15)18/h1-2,6-8,16-17H,3-4H2,(H2,13,14,18)/t6-,7+,8-,10-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 47 mg/mL (160.{{Nemiralisib} site|{Nemiralisib} PI3K|{Nemiralisib} Protocol|{Nemiralisib} In Vivo|{Nemiralisib} supplier|{Nemiralisib} Epigenetics} 04 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|The 5′-triphosphate form of ALS-8112 (ALS-8112-TP) is the active form of the drug and selectively inhibits RSV polymerase through chain termination of RNA synthesis.{{Luteolin} web|{Luteolin} Apoptosis|{Luteolin} Technical Information|{Luteolin} In Vivo|{Luteolin} supplier|{Luteolin} Cancer} ALS-008112 enters various types of epithelial cells in the respiratory tract and is subsequently phosphorylated to form an intracellular nucleoside triphosphate with a half-life of approximately 29 hours.PMID:23672196 The nucleoside triphosphate analogue inhibits RSV replication by means of chain termination. ALS-8112 is a pan-strain inhibitor of RSV replication in vitro. The RNA transcription activity of the RSV–RNP complex is dose-proportionally inhibited by ALS-8112-TP with an IC50 of 0.020 ± 0.008 μM.|Products are for research use only. Not for human use.|
