Product Name :
Rolofylline
Description:
Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment.Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP450).Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases.
CAS:
136199-02-5
Molecular Weight:
356.46
Formula:
C20H28N4O2
Chemical Name:
1,3-dipropyl-8-[(1R,3r,5S,7s)-tricyclo[3.3.1.0³,⁷]nonan-3-yl]-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Smiles :
CCCN1C(=O)C2NC(=NC=2N(CCC)C1=O)[C@]12C[C@@H]3C[C@H]1C[C@H](C2)C3
InChiKey:
PJBFVWGQFLYWCB-OYEQCZOJSA-N
InChi :
InChI=1S/C20H28N4O2/c1-3-5-23-16-15(17(25)24(6-4-2)19(23)26)21-18(22-16)20-10-12-7-13(11-20)9-14(20)8-12/h12-14H,3-11H2,1-2H3,(H,21,22)/t12-,13+,14-,20-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment.Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP450).Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases.|Product information|CAS Number: 136199-02-5|Molecular Weight: 356.46|Formula: C20H28N4O2|Chemical Name: 1,3-dipropyl-8-[(1R,3r,5S,7s)-tricyclo[3.{{Lanosterol} MedChemExpress|{Lanosterol} Metabolic Enzyme/Protease|{Lanosterol} Biological Activity|{Lanosterol} Purity|{Lanosterol} custom synthesis|{Lanosterol} Cancer} 3.{{Zileuton} medchemexpress|{Zileuton} Apoptosis|{Zileuton} Technical Information|{Zileuton} Formula|{Zileuton} supplier|{Zileuton} Autophagy} 1.PMID:22943596 0³,⁷]nonan-3-yl]-2,3,6,7-tetrahydro-1H-purine-2,6-dione|Smiles: CCCN1C(=O)C2NC(=NC=2N(CCC)C1=O)[C@]12C[C@@H]3C[C@H]1C[C@H](C2)C3|InChiKey: PJBFVWGQFLYWCB-OYEQCZOJSA-N|InChi: InChI=1S/C20H28N4O2/c1-3-5-23-16-15(17(25)24(6-4-2)19(23)26)21-18(22-16)20-10-12-7-13(11-20)9-14(20)8-12/h12-14H,3-11H2,1-2H3,(H,21,22)/t12-,13+,14-,20-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
