Product Name :
PF-06291874
Description:
PF-06291874 is a highly potent, non-peptide and orally active glucagon receptor antagonist. PF-06291874 is under the study for type 2 diabetes mellitus (T2DM).
CAS:
1393124-08-7
Molecular Weight:
503.51
Formula:
C26H28F3N3O4
Chemical Name:
3-({4-[(1S)-1-{3,5-dimethyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenoxy}butyl]phenyl}formamido)propanoic acid
Smiles :
CCC[C@H](OC1=CC(C)=C(C(C)=C1)N1C=C(C=N1)C(F)(F)F)C1C=CC(=CC=1)C(=O)NCCC(O)=O
InChiKey:
IBDYYOQKQCCSDP-QFIPXVFZSA-N
InChi :
InChI=1S/C26H28F3N3O4/c1-4-5-22(18-6-8-19(9-7-18)25(35)30-11-10-23(33)34)36-21-12-16(2)24(17(3)13-21)32-15-20(14-31-32)26(27,28)29/h6-9,12-15,22H,4-5,10-11H2,1-3H3,(H,30,35)(H,33,34)/t22-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{GLP-1(7-37)} web|{GLP-1(7-37)} GPCR/G Protein|{GLP-1(7-37)} NF-κB|{GLP-1(7-37)} Technical Information|{GLP-1(7-37)} Description|{GLP-1(7-37)} manufacturer}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PF-06291874 is a highly potent, non-peptide and orally active glucagon receptor antagonist. PF-06291874 is under the study for type 2 diabetes mellitus (T2DM).|Product information|CAS Number: 1393124-08-7|Molecular Weight: 503.51|Formula: C26H28F3N3O4|Chemical Name: 3-({4-[(1S)-1-{3,5-dimethyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenoxy}butyl]phenyl}formamido)propanoic acid|Smiles: CCC[C@H](OC1=CC(C)=C(C(C)=C1)N1C=C(C=N1)C(F)(F)F)C1C=CC(=CC=1)C(=O)NCCC(O)=O|InChiKey: IBDYYOQKQCCSDP-QFIPXVFZSA-N|InChi: InChI=1S/C26H28F3N3O4/c1-4-5-22(18-6-8-19(9-7-18)25(35)30-11-10-23(33)34)36-21-12-16(2)24(17(3)13-21)32-15-20(14-31-32)26(27,28)29/h6-9,12-15,22H,4-5,10-11H2,1-3H3,(H,30,35)(H,33,34)/t22-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 30 mg/mL (59.{{Benzbromarone} site|{Benzbromarone} Metabolic Enzyme/Protease|{Benzbromarone} Technical Information|{Benzbromarone} Description|{Benzbromarone} supplier|{Benzbromarone} Autophagy} 58 mM).PMID:23927631 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|PF-06291874 exposure is approximately dose-proportional with a half-life of ∼19.7-22.7 h. PF-06291874 has a fast on and off rate. PF-06291874 is highly bound to human plasma protein, with a mean free fraction of ∼0.55%.|Products are for research use only. Not for human use.|
