Product Name :
FT011
Description:
FT011 is an anti-inflammatory and anti-fibrotic agent that has been reported to attenuate organ damage in diabetic rats with cardiomyopathy and nephropathy. In diabetic rats, FT011 reduced retinal leukostasis, microglial density and mRNA levels of intercellular adhesion molecule-1 (ICAM-1). In Müller cells, FT011 reduced diabetes-induced gliosis and vascular endothelial growth factor (VEGF) immunolabeling and the hyperglycaemic-induced increase in ICAM-1, monocyte chemoattractant protein-1, CCL20, cytokine-induced neutrophil chemoattractant-1, VEGF and IL-6.
CAS:
1001288-58-9
Molecular Weight:
351.35
Formula:
C20H17NO5
Chemical Name:
2-(3-Methoxy-4-propargyloxycinnamoyl)aminobenzoic acid
Smiles :
COC1=CC(=CC=C1OCC#C)/C=C/C(=O)NC1=CC=CC=C1C(O)=O
InChiKey:
UIWZIDIJCUEOMT-PKNBQFBNSA-N
InChi :
InChI=1S/C20H17NO5/c1-3-12-26-17-10-8-14(13-18(17)25-2)9-11-19(22)21-16-7-5-4-6-15(16)20(23)24/h1,4-11,13H,12H2,2H3,(H,21,22)(H,23,24)/b11-9+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Dotriacontane} medchemexpress|{Dotriacontane} Protocol|{Dotriacontane} In Vitro|{Dotriacontane} manufacturer|{Dotriacontane} Cancer}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
FT011 is an anti-inflammatory and anti-fibrotic agent that has been reported to attenuate organ damage in diabetic rats with cardiomyopathy and nephropathy. In diabetic rats, FT011 reduced retinal leukostasis, microglial density and mRNA levels of intercellular adhesion molecule-1 (ICAM-1). In Müller cells, FT011 reduced diabetes-induced gliosis and vascular endothelial growth factor (VEGF) immunolabeling and the hyperglycaemic-induced increase in ICAM-1, monocyte chemoattractant protein-1, CCL20, cytokine-induced neutrophil chemoattractant-1, VEGF and IL-6.|Product information|CAS Number: 1001288-58-9|Molecular Weight: 351.35|Formula: C20H17NO5|Chemical Name: 2-(3-Methoxy-4-propargyloxycinnamoyl)aminobenzoic acid|Smiles: COC1=CC(=CC=C1OCC#C)/C=C/C(=O)NC1=CC=CC=C1C(O)=O|InChiKey: UIWZIDIJCUEOMT-PKNBQFBNSA-N|InChi: InChI=1S/C20H17NO5/c1-3-12-26-17-10-8-14(13-18(17)25-2)9-11-19(22)21-16-7-5-4-6-15(16)20(23)24/h1,4-11,13H,12H2,2H3,(H,21,22)(H,23,24)/b11-9+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (284.{{Salbutamol} MedChemExpress|{Salbutamol} Adrenergic Receptor|{Salbutamol} Purity & Documentation|{Salbutamol} Formula|{Salbutamol} manufacturer|{Salbutamol} Autophagy} 62 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32926338 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|FT011 (100 mg/kg b.i.d., p.o., for 4 weeks) improves the cardiac function and and myocardial remodeling in myocardial infarction rats.|References:|Zhang Y, et al. A new anti-fibrotic drug attenuates cardiac remodeling and systolic dysfunction following experimental myocardial infarction. Int J Cardiol. 2013 Sep 30;168(2):1174-85.Products are for research use only. Not for human use.|
