Product Name :
Thalidomide-Piperazine-PEG1-NH2
Description:
Thalidomide-Piperazine-PEG1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
CAS:
2357111-29-4
Molecular Weight:
429.47
Formula:
C21H27N5O5
Chemical Name:
5-{4-[2-(2-aminoethoxy)ethyl]piperazin-1-yl}-2-(2, 6-dioxopiperidin-3-yl)-2, 3-dihydro-1H-isoindole-1, 3-dione
Smiles :
NCCOCCN1CCN(CC1)C1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O
InChiKey:
RIUULQPSGWRWMY-UHFFFAOYSA-N
InChi :
InChI=1S/C21H27N5O5/c22-5-11-31-12-10-24-6-8-25(9-7-24)14-1-2-15-16(13-14)21(30)26(20(15)29)17-3-4-18(27)23-19(17)28/h1-2,13,17H,3-12,22H2,(H,23,27,28)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Fluralaner} medchemexpress|{Fluralaner} Parasite|{Fluralaner} Technical Information|{Fluralaner} In stock|{Fluralaner} supplier|{Fluralaner} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.{{Bevacizumab} medchemexpress|{Bevacizumab} Protein Tyrosine Kinase/RTK|{Bevacizumab} Protocol|{Bevacizumab} References|{Bevacizumab} supplier|{Bevacizumab} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33234697
Additional information:
Thalidomide-Piperazine-PEG1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.|Product information|CAS Number: 2357111-29-4|Molecular Weight: 429.47|Formula: C21H27N5O5|Chemical Name: 5-{4-[2-(2-aminoethoxy)ethyl]piperazin-1-yl}-2-(2, 6-dioxopiperidin-3-yl)-2, 3-dihydro-1H-isoindole-1, 3-dione|Smiles: NCCOCCN1CCN(CC1)C1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O|InChiKey: RIUULQPSGWRWMY-UHFFFAOYSA-N|InChi: InChI=1S/C21H27N5O5/c22-5-11-31-12-10-24-6-8-25(9-7-24)14-1-2-15-16(13-14)21(30)26(20(15)29)17-3-4-18(27)23-19(17)28/h1-2,13,17H,3-12,22H2,(H,23,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|References:|Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1000.Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.Products are for research use only. Not for human use.|
