Product Name :
CYC116
CAS No.:
693228-63-6
Purity :
> 99%
Shipping:
Shipped on dry ice.
Storage :
Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month
SMILES:
CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4
Product Description :
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.{{374101-64-1} medchemexpress|{374101-64-1} Protocol|{374101-64-1} Data Sheet|{374101-64-1} manufacturer} 0 nM/9.{{2436544-27-1} web|{2436544-27-1} Protocol|{2436544-27-1} In stock|{2436544-27-1} supplier} 2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A.PMID:30969687 Phase 1.
Formula:
C18H20N6OS
Molecular Weight :
368.46
Synonyms:
Additional Information:
|CAS No. 693228-63-6 ; |Formula C18H20N6OS ; |Molecular Weight 368.46 ; |SMILES CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4 ; |Product Description CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1. ; |Purity > 99% ; |Shipping Shipped on dry ice. ; |Storage Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month ; |Solubility Overview Soluble in DMSO
