Product Name :
(S, R, S)-AHPC-C2-NH2 dihydrochloride
Description:
(S, R, S)-AHPC-C2-NH2 dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S, R, S)-AHPC-OH can be used in the synthesis of a series of PROTACs.
CAS:
2341796-73-2
Molecular Weight:
574.56
Formula:
C25H37Cl2N5O4S
Chemical Name:
(2S, 4R)-1-[(2S)-2-(3-aminopropanamido)-3, 3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1, 3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide dihydrochloride
Smiles :
Cl.Cl.CC1N=CSC=1C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCN)C(C)(C)C)C=C1
InChiKey:
KPAQKVPFCMFPJU-XUKLEHFWSA-N
InChi :
InChI=1S/C25H35N5O4S.2ClH/c1-15-21(35-14-28-15)17-7-5-16(6-8-17)12-27-23(33)19-11-18(31)13-30(19)24(34)22(25(2,3)4)29-20(32)9-10-26;;/h5-8,14,18-19,22,31H,9-13,26H2,1-4H3,(H,27,33)(H,29,32);2*1H/t18-,19+,22-;;/m1../s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
(S, R, S)-AHPC-C2-NH2 dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S, R, S)-AHPC-OH can be used in the synthesis of a series of PROTACs.|Product information|CAS Number: 2341796-73-2|Molecular Weight: 574.56|Formula: C25H37Cl2N5O4S|Chemical Name: (2S, 4R)-1-[(2S)-2-(3-aminopropanamido)-3, 3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1, 3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide dihydrochloride|Smiles: Cl.Cl.CC1N=CSC=1C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCN)C(C)(C)C)C=C1|InChiKey: KPAQKVPFCMFPJU-XUKLEHFWSA-N|InChi: InChI=1S/C25H35N5O4S.2ClH/c1-15-21(35-14-28-15)17-7-5-16(6-8-17)12-27-23(33)19-11-18(31)13-30(19)24(34)22(25(2,3)4)29-20(32)9-10-26;;/h5-8,14,18-19,22,31H,9-13,26H2,1-4H3,(H,27,33)(H,29,32);2*1H/t18-,19+,22-;;/m1../s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Loncastuximab} MedChemExpress|{Loncastuximab} Immunology/Inflammation|{Loncastuximab} Purity & Documentation|{Loncastuximab} References|{Loncastuximab} supplier|{Loncastuximab} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{Prexasertib} MedChemExpress|{Prexasertib} Inhibitor|{Prexasertib} Activator|{Prexasertib} Biological Activity|{Prexasertib} Purity|{Prexasertib} custom synthesis} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33200535 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|References:|Jing Liu, et al. Tropomyosin receptor kinase (trk) degradation compounds and methods of use. WO2020038415A1.Products are for research use only. Not for human use.|
