Product Name :
VER-00158411
Description:
VER-00158411 is a checkpoint kinase 1 (CHK1) and CHK2 inhibitor with IC50 values of 4.4 nM and 4.5 nM, respectively.
CAS:
1174664-88-0
Molecular Weight:
538.64
Formula:
C31H34N6O3
Chemical Name:
1-benzyl-N-(5-{5-[3-(dimethylamino)-2,2-dimethylpropoxy]-1H-indol-2-yl}-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazole-4-carboxamide
Smiles :
CN(C)CC(C)(C)COC1C=C2C=C(NC2=CC=1)C1=CC(=CNC1=O)NC(=O)C1C=NN(CC2C=CC=CC=2)C=1
InChiKey:
REQMZUHAMVOEON-UHFFFAOYSA-N
InChi :
InChI=1S/C31H34N6O3/c1-31(2,19-36(3)4)20-40-25-10-11-27-22(12-25)13-28(35-27)26-14-24(16-32-30(26)39)34-29(38)23-15-33-37(18-23)17-21-8-6-5-7-9-21/h5-16,18,35H,17,19-20H2,1-4H3,(H,32,39)(H,34,38)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{STAT3-IN-20} web|{STAT3-IN-20} JAK/STAT Signaling|{STAT3-IN-20} Activator|{STAT3-IN-20} Biological Activity|{STAT3-IN-20} Formula|{STAT3-IN-20} custom synthesis}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
VER-00158411 is a checkpoint kinase 1 (CHK1) and CHK2 inhibitor with IC50 values of 4.4 nM and 4.5 nM, respectively.|Product information|CAS Number: 1174664-88-0|Molecular Weight: 538.64|Formula: C31H34N6O3|Chemical Name: 1-benzyl-N-(5-{5-[3-(dimethylamino)-2,2-dimethylpropoxy]-1H-indol-2-yl}-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazole-4-carboxamide|Smiles: CN(C)CC(C)(C)COC1C=C2C=C(NC2=CC=1)C1=CC(=CNC1=O)NC(=O)C1C=NN(CC2C=CC=CC=2)C=1|InChiKey: REQMZUHAMVOEON-UHFFFAOYSA-N|InChi: InChI=1S/C31H34N6O3/c1-31(2,19-36(3)4)20-40-25-10-11-27-22(12-25)13-28(35-27)26-14-24(16-32-30(26)39)34-29(38)23-15-33-37(18-23)17-21-8-6-5-7-9-21/h5-16,18,35H,17,19-20H2,1-4H3,(H,32,39)(H,34,38)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Tegafur-Uracil} site|{Tegafur-Uracil} Purity & Documentation|{Tegafur-Uracil} Formula|{Tegafur-Uracil} supplier|{Tegafur-Uracil} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:33353435 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Cellular sensing of DNA damage, along with concomitant cell cycle arrest, is mediated by a great many proteins and enzymes. One focus of pharmaceutical development has been the inhibition of DNA damage signaling, and checkpoint kinases (CHKs). There have been a number of clinical trial of checkpoint kinase inhibits alone or as a combination therapy for example, as a means to sensitize proliferating tumor cells to chemotherapies that damage DNA. The development of checkpoint kinase inhibitors the treatment of cancer was a major objective in drug discovery.|Products are for research use only. Not for human use.|
