Product Name :
Thalidomide-Propargyne-PEG2-COOH
Description:
Thalidomide-Propargyne-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
CAS:
Molecular Weight:
428.39
Formula:
C21H20N2O8
Chemical Name:
3-[2-({3-[2-(2, 6-dioxopiperidin-3-yl)-1, 3-dioxo-2, 3-dihydro-1H-isoindol-5-yl]prop-2-yn-1-yl}oxy)ethoxy]propanoic acid
Smiles :
OC(=O)CCOCCOCC#CC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O
InChiKey:
KZTYSRQJBNPAOM-UHFFFAOYSA-N
InChi :
InChI=1S/C21H20N2O8/c24-17-6-5-16(19(27)22-17)23-20(28)14-4-3-13(12-15(14)21(23)29)2-1-8-30-10-11-31-9-7-18(25)26/h3-4,12,16H,5-11H2,(H,25,26)(H,22,24,27)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Thalidomide-Propargyne-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.|Product information|Molecular Weight: 428.39|Formula: C21H20N2O8|Chemical Name: 3-[2-({3-[2-(2, 6-dioxopiperidin-3-yl)-1, 3-dioxo-2, 3-dihydro-1H-isoindol-5-yl]prop-2-yn-1-yl}oxy)ethoxy]propanoic acid|Smiles: OC(=O)CCOCCOCC#CC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O|InChiKey: KZTYSRQJBNPAOM-UHFFFAOYSA-N|InChi: InChI=1S/C21H20N2O8/c24-17-6-5-16(19(27)22-17)23-20(28)14-4-3-13(12-15(14)21(23)29)2-1-8-30-10-11-31-9-7-18(25)26/h3-4,12,16H,5-11H2,(H,25,26)(H,22,24,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Amitriptyline} web|{Amitriptyline} Histamine Receptor|{Amitriptyline} Biological Activity|{Amitriptyline} In Vivo|{Amitriptyline} supplier|{Amitriptyline} Cancer} |Shelf Life: ≥12 months if stored properly.{{D(+)-Galactosamine} MedChemExpress|{D(+)-Galactosamine} Technical Information|{D(+)-Galactosamine} In stock|{D(+)-Galactosamine} manufacturer|{D(+)-Galactosamine} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32487918 |Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-989.Products are for research use only. Not for human use.|
