Product Name :
MAPK13-IN-1
Description:
MPAK13-IN-1 is a MAPK13 (p38δ) inhibitor, with an IC50 of 620 nM.
CAS:
229002-10-2
Molecular Weight:
365.43
Formula:
C20H23N5O2
Chemical Name:
3-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-1-[4-(pyridin-4-yloxy)phenyl]urea
Smiles :
CN1N=C(C=C1NC(=O)NC1C=CC(=CC=1)OC1C=CN=CC=1)C(C)(C)C
InChiKey:
MHSLDASSAFCCDO-UHFFFAOYSA-N
InChi :
InChI=1S/C20H23N5O2/c1-20(2,3)17-13-18(25(4)24-17)23-19(26)22-14-5-7-15(8-6-14)27-16-9-11-21-12-10-16/h5-13H,1-4H3,(H2,22,23,26)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MPAK13-IN-1 is a MAPK13 (p38δ) inhibitor, with an IC50 of 620 nM.|Product information|CAS Number: 229002-10-2|Molecular Weight: 365.43|Formula: C20H23N5O2|Chemical Name: 3-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-1-[4-(pyridin-4-yloxy)phenyl]urea|Smiles: CN1N=C(C=C1NC(=O)NC1C=CC(=CC=1)OC1C=CN=CC=1)C(C)(C)C|InChiKey: MHSLDASSAFCCDO-UHFFFAOYSA-N|InChi: InChI=1S/C20H23N5O2/c1-20(2,3)17-13-18(25(4)24-17)23-19(26)22-14-5-7-15(8-6-14)27-16-9-11-21-12-10-16/h5-13H,1-4H3,(H2,22,23,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 250 mg/mL (684.13 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Vorapaxar} web|{Vorapaxar} GPCR/G Protein|{Vorapaxar} Technical Information|{Vorapaxar} Purity|{Vorapaxar} manufacturer|{Vorapaxar} Cancer} |Shelf Life: ≥360 days if stored properly.{{Maraviroc} medchemexpress|{Maraviroc} GPCR/G Protein|{Maraviroc} Biological Activity|{Maraviroc} In Vivo|{Maraviroc} custom synthesis|{Maraviroc} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32351194 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MPAK13-IN-1 exhibits an IC50 of 4.63 μM in vero E6 cells.|References:|Yurtsever Z, et al. First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes. Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2335-2344.Mehdi Bouhaddou, et al. The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. 2020 Aug 6;182(3):685-712.e19.Products are for research use only. Not for human use.|
